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Treatment Sequencing Approaches for Patients With HER2+ mBC

Joseph Gligorov, MD, recommends using tucatinib in combination with trastuzumab and capecitabine as a preferred strategy after trastuzumab deruxtecan, favoring it over another antibody-drug conjugate (ADC) due to limited data on the latter's effectiveness. ....

Real World Evidence , Sequencing Approaches , Patients With , Breast Cancer , Metastatic Breast Cancer , Her2 Metastatic Breast Cancer , Her2 Positive Breast Cancer , Advanced Her2 Positive , Drug Approvals , T Dx1 , Therapy Considerations , Stable Brain Metastases , Active Brain Metastases , Her2climb 05 ,

Trastuzumab Deruxtecan for Patients With HER2+ Metastatic Breast Cancer (mBC)

Dr Joseph Gligorov highlights the impact of trastuzumab deruxtecan in treating HER2-positive breast cancer due to its impressive results in progression-free survival and overall survival, emphasizing its importance in early treatment, while acknowledging the need to monitor safety issues. ....

Trastuzumab Deruxtecan , Real World Evidence , Patients With , Metastatic Breast Cancer , Breast Cancer , Her2 Metastatic Breast Cancer , Her2 Positive Breast Cancer , Advanced Her2 Positive , Drug Approvals , T Dx1 , Therapy Considerations , Stable Brain Metastases , Active Brain Metastases , Her2climb 05 ,

Global Perspectives: Evolution of Advanced HER2+ Breast Cancer Treatment

Joseph Gligorov, MD, reviews advances in the treatment of advanced HER2+ breast cancer, shares his global perspective, and explains how ESMO and NCCN guidelines are similar. ....

Real World Evidence , Breast Cancer , Metastatic Breast Cancer , Her2 Metastatic Breast Cancer , Her2 Positive Breast Cancer , Advanced Her2 Positive , Drug Approvals , T Dx1 , Therapy Considerations , Stable Brain Metastases , Active Brain Metastases , Her2climb 05 ,

Adverse Events Seen With Second- and Third-Line Therapies in Patients With HER2+ mBC

Jane Meisel, MD, discusses managing adverse events in patients receiving second- or third-line treatments for HER2+ metastatic breast cancer, emphasizing close monitoring, patient communication, and symptom-specific interventions. ....

Real World Evidence , Events Seen With , Third Line Therapies , Patients With , Breast Cancer , Metastatic Breast Cancer , Her2 Metastatic Breast Cancer , Her2 Positive Breast Cancer , Advanced Her2 Positive , Drug Approvals , T Dx1 , Therapy Considerations , Stable Brain Metastases , Active Brain Metastases , Her2climb 05 ,

The Role of Trastuzumab Deruxtecan in the Treatment of HER2+ mBC

Jane Meisel, MD, elaborates on the evolution and significance of the antibody-drug conjugate trastuzumab deruxtecan in treating HER2+ metastatic breast cancer, highlighting its effectiveness and considerations for its usage. ....

Trastuzumab Deruxtecan , Real World Evidence , Breast Cancer , Metastatic Breast Cancer , Her2 Metastatic Breast Cancer , Her2 Positive Breast Cancer , Advanced Her2 Positive , Drug Approvals , T Dx1 , Therapy Considerations , Stable Brain Metastases , Active Brain Metastases , Her2climb 05 ,