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Study unveils ATP as a key player in ovulation, paves the way for novel infertility treatments

Research explores the role of ATP as a potential neurotransmitter in stimulating kisspeptin neurons to induce ovulation in rodents. The findings shed light on the neurobiological mechanisms involved in ovulation and may have implications for understanding and treating ovulation disorders. ....

Yoshihisa Uenoyama , Safiullah Hazim , Naoko Inoue , Hiroko Tsukamura , Emily Henderson , School Of Bioagricultural Sciences , Nagoya University , Associate Professor Naoko Inoue , Associate Professor Yoshihisa Uenoyama , Professor Hiroko Tsukamura , Graduate School , Bioagricultural Sciences , Hindbrain Adenosine , Purinergic Signaling Triggers , Image Credit ,

Hormone 'pulses' that govern fertility are regulated by brain cells

Hormone 'pulses' that govern fertility are regulated by brain cells
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Hiroko Tsukamura , Nagoya University , Proceedings Of The National Academy Sciences , Professor Hiroko Tsukamura , National Academy , Professor Tsukamura , நாகோயா பல்கலைக்கழகம் , தேசிய கலைக்கழகம் ,

New approach could treat infertility caused by abnormal GnRH secretion


New approach could treat infertility caused by abnormal GnRH secretion
Reports suggest that at least 25% of ovarian disorders are due to dysfunction of the brain mechanism in the hypothalamus that controls the gonadotropin-releasing hormone (GnRH), which is a molecule that governs the reproductive function in men and women by regulating the release of a range of reproductive hormones into the body, particularly gonadotropins, from the pituitary gland, which is located underneath the brain.
In a healthy individual, GnRH and gonadotropins are released in pulses, while typically in individuals whose infertility is caused by hypothalmic dysfunction, the GnRH and gonadotropin pulses are supressed. ....

Japan General , Hiroko Tsukamura , Emily Henderson , Nagoya University , Proceedings Of The National Academy Sciences , School Of Bioagricultural Science , University Of Tokyo , National Institute , Physiological Sciences , Okazaki City , National Academy , Graduate School , Bioagricultural Science , Professor Hiroko Tsukamura , Kei Ichiro Maeda , Project Leader , Professor Uenoyama , Gene Therapy , Pituitary Gland , Reproductive Hormones , Viral Vector , ஜப்பான் ஜநரல் , எமிலி ஹென்டர்சன் , நாகோயா பல்கலைக்கழகம் , பல்கலைக்கழகம் ஆஃப் டோக்கியோ , தேசிய நிறுவனம் ,

Recovery of ovarian function in infertile mammals lacking gonadotropin release


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IMAGE: This study has found that KNDy neurons are key to controlling ovarian function in mammals. These neurons express signalling molecules (peptides) in the brain that stimulate pulses of a hormone.
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Credit: Sho Nakamura
Gonadotropins are any hormones that are released from the anterior pituitary to stimulate the gonads, or sex glands, to carry out their reproductive functions. The gonadotropin-releasing hormone (GnRH) is therefore fundamental for mammalian reproduction. In a healthy reproductive system GnRH is produced by the brain in pulses. Reports suggest that at least 25% of ovarian disorders are due to dysfunction of the brain mechanism controlling the release of gonadotropins, which is a kind of reproductive disorder associated with the hypothalamus. ....

Japan General , Hiroko Tsukamura , Mayuko Nagae , Bio Research At Nagoya University , Program Of Transformative Chem , School Of Bioagricultural Science , Technology Research Promotion Program For Agriculture , Nagoya University , Proceedings Of The National Academy Sciences , University Of Tokyo , Japan Society For The Promotion Of Science , Graduate School , Bioagricultural Science , National Institute , Physiological Sciences , Okazaki City , National Academy , Kei Ichiro Maeda , Associate Professor Uenoyama , Natl Acad Sci United , Japan Society , Cooperative Study Program , Graduate Program , Transformative Chem Bio Research , Professor Kei Ichiro Maeda , Basic Research Activities ,