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Existing drug may be effective in treating SARS-CoV-2


Existing drug may be effective in treating SARS-CoV-2
Scientists from the University of Chicago have found that the drug masitinib may be effective in treating COVID-19.
The drug, which has undergone several clinical trials for human conditions but has not yet received approval to treat humans, inhibited the replication of SARS-CoV-2, the virus that causes COVID-19, in human cell cultures and in a mouse model, leading to much lower viral loads.
X-ray crystallography gave us a strong indication of how this drug works, and we became confident that it has a chance to work in humans.
Nir Drayman, University of Chicago ....

Glenn Randall , Andrzej Joachimiak , Savas Tay , Emily Henderson , University Of Chicago , Argonne National Laboratory , Structural Biology Center , University Of Louisville , Us Department Of Energy , Howard Taylor Ricketts Laboratory , Pritzker School , Molecular Engineering , Advanced Photon Source , Energy Office , Science User Facility , Nir Drayman , Howard Taylor Ricketts , க்ளென் ரேண்டால் , சவாஸ் தாய் , எமிலி ஹென்டர்சன் , பல்கலைக்கழகம் ஆஃப் சிகாகோ , ஆர்கோன் தேசிய ஆய்வகம் , கட்டமைப்பு உயிரியல் மையம் , பல்கலைக்கழகம் ஆஃப் லூயிஸ்வில்லி , எங்களுக்கு துறை ஆஃப் ஆற்றல் , பிரீதிஜ்கேர் பள்ளி ,

Existing drug may be effective in treating COVID-19


Existing drug may be effective in treating COVID-19
A new University of Chicago study has found that the drug masitinib may be effective in treating COVID-19.
The drug, which has undergone several clinical trials for human conditions but has not yet received approval to treat humans, inhibited the replication of SARS-CoV-2 in human cell cultures and in a mouse model, leading to much lower viral loads.
Researchers at UChicago s Pritzker School of Molecular Engineering (PME), working with collaborators at Argonne National Laboratory and around the world, also found that the drug could be effective against many types of coronaviruses and picornaviruses. Because of the way it inhibits replication, it has also been shown to remain effective in the face of COVID-19 variants. ....

Glenn Randall , Savas Tay , Andrzej Jaochimaik , Emily Henderson , Uchicago Pritzker School Of Molecular Engineering , University Of Chicago , Argonne National Laboratory , University Of Louisville , Howard Taylor Ricketts Laboratory , Pritzker School , Molecular Engineering , Nir Drayman , Argonne National , க்ளென் ரேண்டால் , சவாஸ் தாய் , எமிலி ஹென்டர்சன் , உசிக்கோ பிரீதிஜ்கேர் பள்ளி ஆஃப் மூலக்கூறு பொறியியல் , பல்கலைக்கழகம் ஆஃப் சிகாகோ , ஆர்கோன் தேசிய ஆய்வகம் , பல்கலைக்கழகம் ஆஃப் லூயிஸ்வில்லி , பிரீதிஜ்கேர் பள்ளி , மூலக்கூறு பொறியியல் , நீர் டிரேமேன் , ஆர்கோன் தேசிய ,