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Afucosylated monoclonal antibodies (mAb) have been shown to demonstrate an increased binding affinity. To this end, Sino Biological has established a process for afucosylated mAb expression that helps produce antibodies with higher therapeutic efficiency.
Melioidosis is a life-threatening infectious disease caused by the gram-negative bacillus Burkholderia pseudomallei. An effective vaccine is needed, but data on protective immune responses in human melioidosis are lacking. We used ELISA and an antibody-dependent cellular phagocytosis assay to identify the major features of protective antibodies in patients with acute melioidosis in Thailand. We found that high levels of B. pseudomallei–specific IgG2 are associated with protection against death in a multivariable logistic regression analysis adjusting for age, diabetes, renal disease, and ...