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Detection of rare cells and circulating tumor cells using flow cytometric methods


27 January 2021
Circulating tumor cells (CTC) are rare cells shed from a solid tumor or metastases that circulate through the bloodstream. Detection of CTC poses a challenge because they are present at extremely low concentrations, as few as a couple CTC in several milliliters of blood, which contain up to 3 to 6 million cells per mL. To determine the sensitivity and accuracy of rare cell detection on the Agilent NovoCyte Quanteon flow cytometer, a tumor cell spiking assay was used in which a small number of cells from a tumor cell line was added to whole blood and detected by a cell surface stain. ....

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Researchers Build Models Using Machine Learning Technique to Enhance Predictions of COVID-19 Outcomes


Mount Sinai
Mount Sinai researchers have published one of the first studies using a machine learning technique called “federated learning” to examine electronic health records to better predict how COVID-19 patients will progress. The study was published in the Journal of Medical Internet Research – Medical Informatics on January 27.
The researchers said the emerging technique holds promise to create more robust machine learning models that extend beyond a single health system without compromising patient privacy. These models, in turn, can help triage patients and improve the quality of their care.
Federated learning is a technique that trains an algorithm across multiple devices or servers holding local data samples but avoids clinical data aggregation, which is undesirable for reasons including patient privacy issues. Mount Sinai researchers implemented and assessed federated learning models using data from electronic health records at five separate hospitals ....

Benjamin Glicksberg , Mount Sinai Clinical Intelligence Center , Health System , Icahn School Of Medicine At Mount Sinai , Genomic Sciences , Journal Of Medical Internet Research , Department Of Genetics , Mount Sinai , Medical Internet Research , Medical Informatics , Assistant Professor , Icahn School , Hasso Plattner Institute , Digital Health , Mount Sinai Clinical Intelligence , Akhil Vaid , Machine Learning , ஏற்ற சினை மருத்துவ உளவுத்துறை மையம் , ஆரோக்கியம் அமைப்பு , இக்ஹ்ன் பள்ளி ஆஃப் மருந்து இல் ஏற்ற சினை , இதழ் ஆஃப் மருத்துவ இணையதளம் ஆராய்ச்சி , துறை ஆஃப் ஜெநெடிக்ஸ் , ஏற்ற சினை , மருத்துவ இணையதளம் ஆராய்ச்சி , மருத்துவ தகவல் , உதவியாளர் ப்ரொஃபெஸர் ,