Protein employs twist‐and‐squeeze mechanism to expel chemotherapeutics from cancer cells
Protein employs twist‐and‐squeeze mechanism to expel chemotherapeutics from cancer cells In 1986, cellular biochemist Kazumitsu Ueda, currently at Kyoto University's Institute for Integrated Cell-Material Sciences (iCeMS), discovered that a protein called ABCB1 could transport multiple chemotherapeutics out of some cancer cells, making them resistant to treatment. How it did this has remained a mystery for the past 35 years. Now, his team has published a review in the journal FEBS Letters, summarizing what they have learned following years of research on this and other ATP-binding casset...
Source: news-medical.net