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Synthetic biology circuits can respond within seconds


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Synthetic biology offers a way to engineer cells to perform novel functions, such as glowing with fluorescent light when they detect a certain chemical. Usually, this is done by altering cells so they express genes that can be triggered by a certain input.
 
However, there is often a long lag time between an event such as detecting a molecule and the resulting output, because of the time required for cells to transcribe and translate the necessary genes. MIT synthetic biologists have now developed an alternative approach to designing such circuits, which relies exclusively on fast, reversible protein-protein interactions. This means that there’s no waiting for genes to be transcribed or translated into proteins, so circuits can be turned on much faster within seconds. ....

Bonnie Berger , Brian Teague , Ron Weiss , Tristan Bepler , Deepak Mishra , National Science Foundation Graduate Research Fellowship Program , Artificial Intelligence Laboratory , Department Of Biological Engineering , Institute For Collaborative Biotechnologies , National Institutes Of Health , National Science Foundation , Department Of Biochemistry , University Of Wisconsin , Us Army Research Office , Energy Research Fellowship , Biological Engineering , Simons Professor , Jim Broach , Molecular Biology , Penn State Hershey Medical , Siebel Scholars Award , Research Fellowship , Collaborative Biotechnologies , Research Office , Integrated Synthetic Biology , National Institutes ,