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New study defines clinical phenotype of Post-infectious ME/CFS, highlighting unique biomarker insights

The pathophysiological mechanisms of PI myalgic encephalitis/chronic fatigue syndrome (ME/CFS). ....

Nature Communications , Chronic Fatigue Syndrome , Ene Expression , Heart Rate , Myalgic Encephalomyelitis ,

AI tool helps develop the most complete map of the bacterial essential interactome

Universitat Autonoma de Barcelona (UAB) researchers have produced the most complete map of the bacterial essential interactome, i.e. how proteins combine and interact to perform functions essential for their survival. ....

Comunidad Autonoma De Cataluna , Department Of Biochemistry , Autonoma De Barcelona , Molecular Biology , Universitat Aut , Marc Torrent Burgas , Artificial Intelligence , Cell Division , Cell Membrane , Dna Replication , Molecular Biology ,

How SARS-CoV-2 hijacks Fragile X proteins to fuel infection: New clues in COVID-19 and genetic disorders

Study explores the interaction between SARS-CoV-2's non-structural protein 3 (NSP3) and proteins related to Fragile X mental retardation (FMRPs), shedding light on COVID-19 pathophysiology. The research suggests that the virus exploits these host cell proteins for effective infection and possibly interferes with antiviral defense mechanisms, offering new insights into the genetic basis of Fragile X syndrome. ....

Pooja Toshniwal Paharia , Pooja Toshniwal Pahariasep , Pooja Toshniwal , Henrietta Lacks , Coronavirus Disease Covid 19 , Ars Cov 2 , Fragilex Syndrome , Mass Spectrometry , Mental Retardation , Ibonucleic Acid , Evere Acute Respiratory , Evere Acute Respiratory Syndrome , Structural Protein ,

Interactomics-based analysis suggests that rhinitis and rhinitis with asthma are mechanistically different diseases

Researchers used human transcriptomic data to differentiate the molecular mechanisms associated with two phenotypes of allergic rhinitis: rhinitis and rhinitis with asthma. ....

Neha Mathur , Budimir Jevtic Shutterstock , Sophia Coveney , Neha Mathuraug , Mechanisms Of The Development Allergy Me , Scientific Reports , Allergic Rhinitis ,

A network of interacting proteins created to aid drug discovery

Scientists at Open Targets, EMBL's European Bioinformatics Institute, and GSK are revealing the shared basis of diseases using a map of interacting human proteins. ....

Inigo Barrio Hernandez , Ellen Mcdonagh , Barrio Hernandez , Pedro Beltrao , Emily Henderson , European Bioinformatics Institute , Group Leader , Genome Wide Association Studies , Open Targets , Bioinformatics Institute , Wide Association Studies , Nature Genetics , Discovery Industry Focus , Inflammatory Bowel Disease , Associate Professor , Informatics Science , Drug Discovery , Cell Biology , Drug Repurposing ,