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Ketamine may be an alternative to shock treatment for people with treatment-resistant major depression, a new study suggests.

The atypical antipsychotic cariprazine, which is approved for schizophrenia and bipolar disorder, is also effective as an adjunct treatment for resistant depression, results of a new phase 3 trial show.

Lamar Odom says regular, hour-long ketamine therapy sessions helped him through his addiction. Here's how it works. INSIDER 2 days ago Former NBA Star Lamar Odom said medically supervised ketamine therapy helps him stay sober. Mounting evidence suggests ketamine, often used as a party drug, can treat depression. Odom, who overdosed in 2015, said he no longer feels a pull to do hard drugs when he has difficult moments. Lamar Odom said taking the hallucinogenic drug ketamine for the past two years has aided his recovery from drug addiction. During a Monday interview on Good Morning America, t...

Mount Sinai Researchers from the Icahn School of Medicine at Mount Sinai have identified a drug that works against depression by a completely different mechanism than existing treatments. Their study showed that ezogabine (also known as retigabine), a drug that opens KCNQ2/3 type of potassium channels in the brain, is associated with significant improvements in depressive symptoms and anhedonia in patients with depression. Anhedonia is the reduced ability to experience pleasure or lack of reactivity to pleasurable stimuli; it is a core symptom of depression and associated with worse outcomes,...

Ion Channel in Brain May Serve as Novel Target for Treating Depression Source: Kiyoshi Hijiki/Getty Images March 4, 2021 Share Researchers from the Icahn School of Medicine at Mount Sinai say they have identified a drug that works against depression by a completely different mechanism than existing treatments. Their study showed that ezogabine (also known as retigabine), a drug that opens KCNQ2/3 type of potassium channels in the brain, is associated with significant improvements in depressive symptoms and anhedonia in patients with depression, according to the team. Anhedonia is the reduced...