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Stem Cell Transplants Promising So Far in Type 1 Diabetes

A second patient who received Vertex s VX-880 has experienced glycemic improvements, whereas the first one is completely insulin-independent. ....

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First patient gains insulin independence with novel stem cell-derived islet cell therapy

NEW ORLEANS — A man with long-standing type 1 diabetes and no endogenous insulin production achieved insulin independence after an infusion of an investigational stem cell-derived pancreatic islet cell therapy, researchers reported.In a proof-of-concept study, treatment with half the target dose of VX-880 (Vertex Pharmaceuticals), a novel allogeneic stem cell-derived, fully differentiated, ....

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T1D Patient Achieves Full Insulin Independence After Stem Cell Transplant

But clinical trial currently under FDA hold as dosing is discussed ....

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iTolerance, Inc. Pre-Clinical Non-Human Primate Study Demonstrates Long-Term Success of Allogeneic Islet Implantation Without Chronic Immunosuppression for the Treatment of Diabetes

iTolerance, Inc. Pre-Clinical Non-Human Primate Study Demonstrates Long-Term Success of Allogeneic Islet Implantation Without Chronic Immunosuppression for the Treatment of Diabetes
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Novel approach allows islet transplants to survive and control diabetes

In type 1 diabetes, an autoimmune response attacks the pancreas's insulin-producing beta cells, leading to marked fluctuations in blood sugar levels. Lifelong daily insulin treatments are standard for patients, but replacing lost beta cells through transplants of islets, a group of cells in the pancreas, represents an attractive option. ....

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