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The star, who has appeared in the role since 2013, admitted to Lorraine Kelly on Tuesday that the news came as a surprise to all involved.
Holby City spoilers - Jaye Jacobs teases final episode and reveals favourite Donna story.
In celebration of Women's History Month, here's our chat with some of the most iconic women of soap.
Jaye Jacobs has played Donna since 2004.
Holby City spoilers as the BBC show offers a first look at Bernie and Serena's surprise return.