Neoadjuvant Regimen Tops Standard for Locally Advanced Rectal Cancer
email article Adding neoadjuvant chemotherapy to preoperative chemoradiotherapy (CRT) for locally advanced rectal cancer led to better disease-free survival (DFS) and less toxicity as compared with a standard regimen of neoadjuvant CRT and adjuvant therapy, a randomized trial showed. DFS at 3 years improved from 69% with standard treatment to 76% with neoadjuvant chemotherapy followed by chemoradiotherapy (CRT) before surgery. Grade 3/4 adverse events (AEs) associated with adjuvant chemotherapy occurred substantially less often in patients who received neoadjuvant chemotherapy, as repor...
Source: medpagetoday.com