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Some of the victims' families have opposed the demolition, calling for the house to be preserved until after Brian Kohberger, the man accused of the slayings, has been tried.
Students Ethan Chapin, Xana Kernodle, Madison Mogen and Kaylee Goncalves were fatally stabbed there in November 2022.
After about three hours, the home was fully demolished and its concrete foundation had been broken up. Multiple dump trucks continued to remove debris from the site.
The owner of the rental home near the university campus in Moscow, Idaho, donated it to the university earlier this year.
Some of the victims' families have opposed the demolition, calling for the house to be preserved until after Brian Kohberger, the man accused of the slayings, has been tried.