Proteomics Begins to Emerge from Genomics' Shadow
Proteomics Begins to Emerge from Genomicsâ Shadow Source: cdascher/Getty Images Where conventional mass spec struggles with sequencing, isoforms, and post-translational modifications, new technologies may shine Compared with RNA or DNA sequencing, protein sequencing got an early start, as early as the 1950s, when Frederick Sanger adapted partition chromatography and other techniques to determine the amino acid sequences of insulinâs A and B chains. Years later, RNA and DNA sequencing appeared, and they quickly began to outpace protein sequencing. They continued to race ahead even a...