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Prototype Sensor Aids Quick Measurement of ATP and Lactate

Researchers have designed a prototype sensor that can aid doctors in quickly measuring adenosine triphosphate (ATP) and lactate levels present in blood samples of patients, helping in the fast assessment of the severity of certain diseases. ....

Akihiko Ishida , Megan Craig , Tokushima University , Institute Of Advanced Medical Sciences , Research Programs , Hokkaido University , Prototype Sensor , Quick Measurement , Lactate Levels , Image Credit , Applied Chemist , Joint Usage , Joint Research Programs , Advanced Medical Sciences ,

Sensor monitors disease severity

Sensor monitors disease severity
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Akihiko Ishida , Manabu Tokeshi , Keine Nishiyama , Tokushima University , Institute Of Advanced Medical Sciences , Research Programs , Members Of The Division Applied Chemistry , Hokkaido University , Applied Chemistry , Joint Usage , Joint Research Programs , Advanced Medical Sciences ,

BCAS3-C16orf70 complex is a new actor on the mammalian autophagic machinery


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IMAGE: The confocal microscopy image of cell induced mitophagy. Autophagic membranes engulf the damaged mitochondria. TOMM20 (blue) is mitochondrial outer membrane protein and WIPI2 (red) is well-known autophagy protein. BCAS3-C16orf70 (green).
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Credit: TMIMS
Autophagy is an intracellular degradation process of cytosolic materials and damaged organelles. Researchers at Ubiquitin Project of TMIMS have been studying the molecular mechanism of mitophagy, the selective autophagy process to eliminate damaged mitochondria. PINK1 (a serine/threonine kinase) and Parkin (a ubiquitin ligating enzyme: E3) work together to ubiquitylate the outer membrane proteins of damaged mitochondria, then ubiquitin chains are recognized as signals for autophagy degradation. Dysfunction of mitophagy causes a decrease in mitochondrial quality with overproduction of ROS, and is linked to neurodegenerative diseases like Parkinson s disease. ....

Life Science Research , Tokushima University , Institute Of Advanced Medical Sciences , Research Programs , University Of Tokushima , Takeda Science Foundation , Chieko Iwanaga Fund For Parkinson Disease Research , National Institute Of Advanced Industrial Science , Ubiquitin Project , Breast Carcinoma Amplified Sequence , National Institute , Advanced Industrial Science , Chieko Iwanaga Fund , Disease Research , Joint Usage , Joint Research Programs , Advanced Medical Sciences , Platform Project , Supporting Drug Discovery , Supporting Innovative Drug Discovery , Molecular Biology , Medicine Health , Biomedical Environmental Chemical Engineering , வாழ்க்கை அறிவியல் ஆராய்ச்சி , டோக்குஷிமா பல்கலைக்கழகம் , ஆராய்ச்சி ப்ரோக்ர்யாம்ஸ் ,