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Researchers use EPR spectroscopy to learn more about Parkinson protein The protein α-synuclein is one of the most abundant proteins in the human brain. It is often referred to as the Parkinson protein , as deposition of this protein in brain cells is a hallmark of Parkinson s disease. Despite the high interest of biomedical research in the protein, many questions concerning the function and physiology of α-synuclein in living cells still remain to be answered. For example, it was previously unclear whether and to what extent the protein binds to and interacts with internal cell components such as membranes. As such processes could play a role in the development of the disease, the team led by Konstanz-based physical chemist Professor Malte Drescher used the further development of an established measurement method called electron paramagnetic resonance spectroscopy (EPR spectroscopy) to learn more about the binding properties of the Parkinson protein . ....
E-Mail IMAGE: Scientists from the University of Konstanz and the Free University of Amsterdam, in collaboration with the Bruker BioSpin development team, have succeeded for the first time in the direct spectroscopic. view more Credit: Malte Drescher Lab - University of Konstanz The protein α-synuclein is one of the most abundant proteins in the human brain. It is often referred to as the Parkinson protein , as deposition of this protein in brain cells is a hallmark of Parkinson s disease. Despite the high interest of biomedical research in the protein, many questions concerning the function and physiology of α-synuclein in living cells still remain to be answered. For example, it was previously unclear whether and to what extent the protein binds to and interacts with internal cell components such as membranes. As such processes could play a role in the development of the disease, the team led by Konstanz-based physical chemist Professor Malte Dresch ....