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Nottinghamshire Police says it has received 44 reports of spiking since September 4. Of those, 12 are alleged to have involved needles, officers say.
Priti Patel has ordered police to update her on the situation, following reports of incidents across the UK, including in Nottingham where a 19-year-old says she was targeted with a needle.
One 19-year-old woman told the BBC she felt "a pinch on the back of her arm" before blacking out while partying with friends in Nottingham.
Ellie Simpson says her sister felt "a pinch on the back of her arm" as she left a nightclub.
A man has been arrested by Nottinghamshire Police following three reports of women being spiked by injection at two Nottingham nightclubs in the last two weeks.