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New genetic variants are found to influence the age at which women attain menopause, thereby giving a detailed understanding of reproductive aging.

Study offers genetic insights into the underlying biology of reproductive aging The age at which women go through menopause is critical for fertility and impacts healthy aging in women, but reproductive aging has been difficult for scientists to study and insights into the underlying biology are limited. Now, scientists have identified nearly 300 gene variations that influence reproductive lifespan in women. Additionally, in mice, they have successfully manipulated several key genes associated with these variants to extend their reproductive lifespan. Their findings, published today in Natur...

Aktualizace: 05.08.2021 08:30 Vydáno: 05.08.2021, 08:30 Těhotná - vyšetření - ilustrační foto. ČTK/AP/ Praha - Vědcům se podařilo identifikovat téměř tři stovky genů ovlivňujících dobu plodnosti u žen. Poznatky by mohly pomoci s léčbou neplodnosti i se zlepšením předpovědi nástupu brzké menopauzy, uvedli zástupci Akademie věd ČR (AV) v tiskové zprávě. Manipulací s vybranými geny výzkumníci dokázali výrazně prodloužit dobu plodnosti u myší. Na výzkumu spolupracovali odborníci ze 180 institucí z různých zemí, včetně vědců z Ústavu živ...

These genetic variants are able to roughly predict the age at which some women will stop having periods, and identify those at risk of early menopause, according to the team from the University of Exeter.