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Patchwork of mutations contributing to bipola

Bipolar disorder (BD) is a serious psychiatric disorder affecting around 1% of the population worldwide. While medications are indispensable for these patients, they are not completely effective, and the underlying genetic architecture and pathogenesis of BD remain unresolved. Researchers from Japan have now used deep exome sequencing to show that mosaic variants/mutations found in genes related to developmental disorders and autism spectrum disease and in the mitochondrial tRNA region could be associated with BD. ....

Japan General , Jun Takayama , Tadafumi Kato , Gen Tamiya , Mizuho Ishiwata , Atsushi Takata , Takashi Hayama , Naomi Sakai , Junko Ueda , Masaki Nishioka , Toshiyuki Someya , Shinichi Kuriyama , Kumiko Fujii , Department Of Molecular Epidemiology , Tohoku University School Of Medicine , Laboratory For Molecular Pathology Of Psychiatric Disorders , Department Of Integrative Genomics , Department Of Psychiatry , Juntendo University , Laboratory For Molecular Dynamics Of Mental Disorders , Shiga University Of Medical Science , Method Of Research , Juntendo University Graduate School Of Medicine , Department Of Preventive Medicine , Statistical Genetics Team , Tohoku Medical Megabank Organization ,