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Total cholesterol and all-cause mortality by sex and age: a prospective cohort study among 12.8 million adults

It is unclear whether associations between total cholesterol (TC) levels and all-cause mortality and the optimal TC ranges for lowest mortality vary by sex and age. 12,815,006 Korean adults underwent routine health examinations during 2001–2004, and were followed until 2013. During follow-up, 694,423 individuals died. U-curve associations were found. In the TC ranges of 50–199 and 200–449 mg/dL, each 39 mg/dL (1 mmol/L) increase in TC was associated with 23% lower (95% CI:23%,24%) and 7% higher (6%,7%) mortality, respectively. In the age groups of 18–34, 35–44, 45–54, 55–64, 65–74, and 75–99 years, each 1 mmol/L higher TC increased mortality by 14%, 13%, 8%, 7%, 6%, and 3%, respectively (P < 0.001 for each age group), for TC ≥ 200 mg/dL, while the corresponding TC changes decreased mortality by 13%, 27%, 34%, 31%, 20%, and 13%, respectively, in the range &l ....

South Korea , Kwangju Gwangyoksi , United States , Republic Of Korea , Institutional Review Board Of Catholic Kwandong University , Institute Inc , Institutional Review Board Of Kwandong University Gangneung , National Health Insurance Service , Korean Metabolic Risk Factor , President Register , Institutional Review Board , Catholic Kwandong University , Observational Studies , Kwandong University ,