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This state of, you know -- >> and why that happens is exactly what columbia university neuroscientist carl hart is investigating. >> exhale. >> research subjects in his lab smoke marijuana and then take a variety of cognitive tests. >> the effects will be disruption in memory, disruptions in inhibitory control. they will become slower at cognitive functioning, a wide range of things. these effects are temporary, but they're pretty pronounced, and they are clear. >> and it's slowly becoming clear to scientists what part of the brain is most affected. it's the prefrontal cortex. >> it's very imp...

>> how do you know when you've done too much? >> simple tasks become very frustrating, like mixing paint, and then just sort of get into this state of, uhhhh, you know? >> and why that happens is exactly what columbia university neuroscientist carl hart is investigating. >> exhale. >> research subjects in his lab smoke marijuana and then take a variety of cognitive tests. >> the effects will be disruption in memory, disruptions in inhibitory control. they will become slower at cognitive functioning, a wide range of things. these effects are temporary, but they're pretty pronounced, and they ar...

>> you can get paranoid and have disorganized thinking. you get disoriented. it can be uncomfortable. it can lead to panic attacks or anxiety attacks in people. >> how do you know when you've done too much? >> simple tasks become very frustrating, like mixing paint, and then just sort of get into this state of, uh, you know. >> and why that happens is exactly what columbia university neuroscientist carl hart is investigating. >> exhale. >> research subjects in his lab smoke marijuana and then take a variety of cognitive tests. >> the effects will be disruption in memory, disruptions in inhibit...

Done too much? >> simple tasks become very frustrating, like mixing paint, and then just sort of get into this state of uh, you know. >> and why that happens is exactly what columbia university neuroscientist carl hart is investigating. >> exhale. >> research subjects in his lab smoke marijuana and then take a variety of cognitive tests. >> the effects will be disruption in memory, disruptions in inhibitory control. they will become slower at cognitive functioning, a wide range of things. these effects are temporary, but they're pretty pronounced, and they are clear. >> and it's slowly becomin...

>> simple tasks become very frustrating, like mixing paint, and then just sort of get into this state of duh, you know. >> and why that happens is exactly what columbia university neuroscientist carl hart is investigating. >> exhale. >> research subjects in his lab smoke marijuana and then take a variety of cognitive tests. >> the effects will be disruption in memory, disruptions in inhibitory control. they will become slower at cognitive functioning, a wide range of things. these effects are temporary, but they're pretty pronounced, and they are clear. >> and it's slowly becoming