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Stranded anywhere. why the funfairs of afghanistan are now men only with women banned by the taliban from many leisure facilities. commentator: and it's rashford! cheering. and after beating wales, england now prepare to face senegal in the last 16 of the world cup. and coming up on the bbc news channel... england's first test in pakistan in 17 years could be delayed by a day after 1a players and staff are hit by a virus in rawalpindi. hello. good afternoon and welcome to the bbc news at one. it's been hailed as a momentous and historic breakthrough — a drug which,

The manufacturer says it could be on the market next year. we're already talking with regulators here. we will be filing in early january. we would hope that this might be available from september time in the uk. you look good when you laugh, you look happy. — the drug has potential side effects such as brain swelling. but despite all the limitations, this is a significant moment in the fight against alzheimer's. fergusjoins me now. you say it is a significant move, how excited should we be about this? it is rare that i use the term breakthrough, but i think it is merited today. why? it is a...

Lecanemab works by clearing amyloid from the brain. david and his wife cheryl can't be sure if the drug is making a difference, but they're delighted to have taken part in the trial. when we first began this two and a half years ago, we didn't necessarily think it would help us, but we felt we were doing something and could help future generations. it's just a horrible, nasty thing. if somebody can slow it down and then eventually get it stopped altogether, you know, it'd be brilliant. at least half a million people across the uk are living with alzheimer's, by far the most common form of deme...

Because of the disease. alzheimer's gradually destroys key areas of the brain involved in memory and understanding. david is one of nearly 2,000 patients who took part in a major trial of a new drug, lecanemab. as normal, if you just lift your arm up there for me. it involved having an infusion every two weeks. lecanemab didn't stop alzheimer's... i'lljust get you started here. ..but over 18 months, it slowed its progression by about a quarter. this is so exciting because now we're getting results, the first results that are indicating that the drug is successfully treating the underlying caus...

It is interesting on the issue of prisoners of war how the pendulum swung. earlier on, it was ukraine that suffered the most captures. but since september, the momentum has very much gone the other way. to fight in wintry conditions, that takes discipline and training. and for ukraine, they are seeing that as an opportunity with russia's partial mobilisation of men. they are hoping this information campaign along with continued military offences will allow them to keep re—taking territory. but it is easier said than done as the conditions do continue to deteriorate. james, thank you very muc...