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Researchers identify novel gene mechanism in most aggressive kidney cancers

In a new study from the Johns Hopkins Kimmel Cancer Center, researchers described a novel mechanism of tumor formation in kidney cancers driven by overexpression of the mechanistic target of rapamycin complex 1 (mTORC1) signaling pathway with loss of the tuberous sclerosis complex (TSC) tumor suppressor gene. ....

Pedram Argani , Adriannaa Mendes , Tamara Lotan , Ethan Schaffer , Thiago Vidotto , Sanjana Murali , Emily Henderson , Clarence Rachel Villanueva , Kaushal Asrani , Hansb Liu , Kewen Feng , Danielac Salles , Nature Communications , Johns Hopkins Kimmel Cancer Center , Johns Hopkins University School Of Medicine , Industry Focus , Juhyung Woo , Lia Oliveira , Brandon Lam , Johns Hopkins University School , Ignaling Pathway , Transcription Factors , Tuberous Sclerosis ,