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Joint government and industry investment will deliver more than 250 high-skilled jobs producing environmentally-friendly inhalers.
The UK invests £33 million in Kindeva Drug Delivery for green inhalers, creating jobs and boosting life sciences manufacturing.
Phosphorylation of G-protein-coupled receptors (GPCRs) by GPCR kinases (GRKs) desensitizes G-protein signalling and promotes arrestin signalling, which is also modulated by biased ligands1–6. The molecular assembly of GRKs on GPCRs and the basis of GRK-mediated biased signalling remain largely unknown owing to the weak GPCR–GRK interactions. Here we report the complex structure of neurotensin receptor 1 (NTSR1) bound to GRK2, Gαq and the arrestin-biased ligand SBI-5537. The density map reveals the arrangement of the intact GRK2 with the receptor, with the N-terminal helix of G...
Bromelain: Your Pineapple’s Secret Recipe for Health and Happiness