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This book offers a general review of the voluminous theoretical and experimental literature pertaining to physical self-replicating systems and self-replication. The principal focus here is on self-replicating machine systems. Most importantly, we are concerned with kinematic self-replicating machines: systems in which actual physical objects, not mere patterns of information, undertake their own replication. Following a brief burst of activity in the 1950s and 1980s, the field of kinematic replicating systems design received new interest in the 1990s with the emerging re...