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This article explores how you can measure particle size CQAs in (sterile) pharmaceutical packaging, and discusses non-invasive measurements using SR-DLS.

In this article, InProcess demonstrates the potential of in-line nanoparticle size measurements using the NanoFlowSizer (NFS) as a PAT method.

Continuous Manufacturing of Liposomal Products DIANT Phar Image Credit: InProcess Continuous manufacturing is starting to gain increased interest over traditional batch processing for nanoparticle drug delivery systems. DIANT Pharma Inc. (DIANT) provides a turnkey solution for the continuous processing of nanoparticles by offering multiple modules and integrated process analytical technology as a single closed-system. Inventors of the Continuous Manufacturing System DIANT is a startup co-founded by Antonio Costa, Ph.D. and Diane Burgess, Ph.D.  In 2020, DIANT licensed their ...

In drug development many applications are found for lipid-based nanoparticles (Lb-NPs) as successful transporters for poorly water-soluble drugs and oligonucleotides in gene therapy.  Major advantages of lipids are their high biocompatibility and biodegradability. In addition, advanced formulations using Lb-NP encapsulation of active ingredients can strongly contribute to targeted drug delivery in the body as well as stability and storage of the formulation. The most important current medical applications include cancer therapeutics and some of the current COVID-19 vaccines.   Developm...