New Bispecific Antibody Approved for Tough-to-Treat Lymphoma
Approval of glofitamab was based on a phase I/II study that showed a 56% overall response rate
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Approval of glofitamab was based on a phase I/II study that showed a 56% overall response rate
Glofitamab is the first bispecific antibody with a fixed-duration treatment for adults with relapsed or refractory diffuse large B-cell lymphoma (DLBCL).
A PD-1 checkpoint inhibitor plus chemotherapy is expected to become new standard of care for advanced lymphoma, based on Phase III trial data.
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A Phase 3 trial has demonstrated that patients with advanced stage (3 or 4) classic Hodgkin lymphoma who underwent initial treatment with nivolumab, a PD-1 checkpoint inhibitor, and AVD chemotherapy (N-AVD) had a significantly lower risk of their cancer getting worse than patients treated with brentuximab vedotin, a monoclonal antibody, and AVD (BV-AVD) a year after starting treatment.