This protein boosts mice life expectancy by an average 30%
An overexpression of SIRT6 increases longevity in engineered mice and enables them to stay vigorous without becoming frail.
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An overexpression of SIRT6 increases longevity in engineered mice and enables them to stay vigorous without becoming frail.
'If we can determine how to activate [this protein] in humans, we will be able to prolong life,' said Professor Haim Cohen.
An overexpression of SIRT6 increases longevity in engineered mice and enables them to stay vigorous without becoming frail.
Aging is associated with an overall decline in health and increased frailty, and is a major risk factor for multiple chronic diseases.
Transgenic mice express high levels of the SIRT6 gene and show that their life expectancy can be increased by an average of 30% in both males and females. The mice exhibited significant improvement in overcoming a variety of age-related diseases and conducted the same level of vigorous activity as young mice, without becoming frail. Through a variety of methods and analyses, the mechanism through which SIRT6 facilitates healthy aging was deciphered.