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<p><strong>&middot; Researchers at the Centre for Genomic Regulation (CRG) , the Spanish National Cancer Research Center (CNIO) and the IBMB-CSIC solve a key problem in biology: how human cells build their microtubules</strong></p> <p><strong>&middot; During cell division, microtubules function as nanometer-thick long &lsquo;ropes&#39; inside cells that pull chromosomes apart so that each daughter cell receives a copy of the genetic material</strong></p> <p><strong>&middot; The work published in <em>Science &...

Credit: CNIO Researchers from the Microtubule Organization lab, headed by Jens Lüders at IRB Barcelona, and the Macromolecular Complexes in DNA Damage Response Group, led by Oscar Llorca at the Spanish National Cancer Research Centre (CNIO), have achieved the first in vitro reconstitution of the human -tubulin ring complex (γTuRC), responsible for initiating microtubule formation. In addition, they revealed its 3D structure by cryo-electron microscopy. The key to their success lies in the identification of the RUVBL protein complex as an essential γTuRC assembly helper. Microtubules are a ...