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Using theoretical models of bacterial metabolism and reproduction, scientists can predict the type of resistance that bacteria will develop when they are...
New model can predict how bacteria develop antibiotic resistance eurekalert.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from eurekalert.org Daily Mail and Mail on Sunday newspapers.
Study shows how new antibiotic resistance genes arise from random DNA sequences An important and still unanswered question is how new genes that cause antibiotic resistance arise. In a new study, Swedish and American researchers have shown how new genes that produce resistance can arise from completely random DNA sequences. The results have been published in the journal PLOS Genetics. Antibiotic resistance is a major global problem and the spread of resistant bacteria causes disease and death, and constitutes a major cost to society. The most common way for bacteria to develop resistance is by taking up various types of resistance genes from other bacteria. These genes encode proteins (peptides) that can lead to resistance by: (i) deactivating the antibiotic, (ii) reducing its concentration, or (iii) altering the antibiotic's target so that the antibiotic can no longer bind to that target and hence halt the growth of the bacterium.
An important and still unanswered question is how new genes that cause antibiotic resistance arise. In a new study, Swedish and American researchers have shown how new genes that produce resistance can arise from completely random DNA sequences. The results have been published in the journal PLOS Genetics.