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Study investigates metformin and other candidate drugs through a network medicine approach

The five-year award from the National Institutes of Health will support expansive atrial fibrillation research by a multidisciplinary team led by Dr. Mina Chung.

Justin Lathia, vice chair of the Department of Cardiovascular & Metabolic Sciences at the Clinic, is one of nine recipients in the United States to receive the Research Program Award from the NIH.

A diet rich in red meat correlates with increased risk for cardiovascular disease but the underlying genetic and biochemical mechanisms for this link have not been clear until now. A new study from researchers at the Cleveland Clinic identifies the genetic machinery and biochemical process through which gut bacteria sequentially convert carnitine present in a red-meat rich diet into a metabolite called TMAO that promotes blood clotting and atherosclerosis.

A Cleveland Clinic-led study has revealed new insights into how a diet rich in red meat increases risk for cardiovascular disease. The findings were published in Nature Microbiology and build on more than a decade of research by lead author Stanley Hazen, MD, PhD.