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Blood vessels grow in difficult metabolic conditions, and recent research has identified two proteins involved in regulating this mechanism.

S-2-hydroxyglutarate keeps endothelial cells in a dormant state, reveals study The inner surface of blood vessels is lined by a wafer-thin layer of cells known as the endothelium, which forms a crucial barrier between blood and the surrounding tissue. The single-layered cell structure promotes the exchange of oxygen and nutrients, while simultaneously preventing the uncontrolled leakage of blood components. Only when the metabolic needs of the surrounding tissue increase, e.g., during growth, wound healing or tumor development, do endothelial cells abandon this stable cell association in orde...

 E-Mail IMAGE: Retinal vessels of a mouse in which S-2-hydroxyglutarate levels are selectively increased in the endothelium. Blood vessels (blue), nuclei of dividing endothelial cells (yellow), resting endothelial cells (green), other cells... view more  Credit: BIH/Michael Potente The inner surface of blood vessels is lined by a wafer-thin layer of cells known as the endothelium, which forms a crucial barrier between blood and the surrounding tissue. The single-layered cell structure promotes the exchange of oxygen and nutrients, while simultaneously preventing the uncontrolled lea...