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Genotoxic E. coli 'caught in the act'

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IMAGE: Immunofluorescence staining shows that genotoxic colibactin-producing E. coli (green) cause DNA damage (indicated by the presence of the DNA repair protein γH2AX, white) and megalocytosis (abnormal enlargement of cells) (right)..
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Credit: Max Planck Institute for Infection Biology / Amina Iftekhar
Escherichia coli bacteria are constitutive members of the human gut microbiota. However, some strains produce a genotoxin called colibactin, which is implicated in the development of colorectal cancer. While it has been shown that colibactin leaves very specific changes in the DNA of host cells that can be detected in colorectal cancer cells, such cancers take many years to develop, leaving the actual process by which a normal cell becomes cancerous obscure. The group of Thomas F. Meyer at the Max Planck Institute for Infection Biology in Berlin together with their collaborators have now been able to catch colibactin in the act of induc ....

Thomasf Meyer , Amina Iftekhar , Michael Sigal , University Hospital , Max Planck Institute For Infection Biology , Max Planck Institute , Infection Biology , Infectious Emerging Diseases , அமினா இப்தெகர் , பல்கலைக்கழகம் மருத்துவமனை , தொற்று உயிரியல் , தொற்று வளர்ந்து வருகிறது நோய்கள் ,

Yair Zakovitch, 'one of the world's most original Bible researchers,' to receive Israel Prize

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Feb. 2, 2021
Professor Yair Zakovitch of the Hebrew University of Jerusalem will be awarded the Israel Prize in Bible studies, Education Minister Yoav Gallant announced on Tuesday.
“Yair Zakovitch is one of the most original Bible researchers in the country and the world,” the prize committee said in a statement on Tuesday, which mentions Zakovitch’s research of the “literary aspects of the Bible, the intra-biblical interpretation and its evolution.”
Zakovitch was born in Haifa and his research revolves around the literary aspects of the Bible and its internal interpretation. “In his works, he developed an exceptional method for identifying interrelationships between the books of the Bible, through word games and interweaving of motifs,” wrote the committee. ....

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