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'Organs-on-a-chip' sheds light on gut microbiome's role in Parkinson's disease


Researchers have developed an organs-on-a-chip system that models the interactions between the brain, gut microbiome, liver, and colon in patients with Parkinson’s disease.
The system allows the research team to more fully understand the gut-brain axis’ role in neurological diseases, better replicating the complex interactions that murine mice models struggle to do.
The team from Massachusetts Institute of Technology (MIT) found that short-chain fatty acids (SCFAs) produced by gut microbes are transported to the brain, where they have different effects on healthy and diseased brain cells.
“While short-chain fatty acids are largely beneficial to human health, we observed that under certain conditions they can further exacerbate certain brain pathologies, such as protein misfolding and neuronal death, related to Parkinson’s disease,” ​says Martin Trapecar, an MIT postdoc and the lead author of the study. ....

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The global microfluidic devices market is projected to reach US$ 22.65 Billion by 2026

The global microfluidic devices market is projected to reach US$ 22.65 Billion by 2026
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