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Researchers identify new strategy to protect offspring from prenatal stress New research from the University of Iowa and University Hospitals Cleveland Medical Center demonstrates that offspring can be protected from the effects of prenatal stress by administering a neuroprotective compound during pregnancy. Working in a mouse model, Rachel Schroeder, a student in the UI Interdisciplinary Graduate Program in Neuroscience, drew a connection between the work of her two mentors, Hanna Stevens, MD, PhD, UI associate professor of psychiatry and Ida P. Haller Chair of Child and Adolescent Psychiatr...

Inflammation of the brain gray matter decreases nerve-cell activity in mouse model Damage to the brain gray matter plays an important role in the progression of multiple sclerosis. This study now shows that such damage can be caused by inflammatory reactions that lead to loss of synapses, which impairs neural activity. Multiple sclerosis (MS) is a chronic inflammatory disease that affects the central nervous system, in which nerve cells are attacked by the patient's own immune system. In many cases, the disease develops into a progressive form, which is characterized by a shift of pathology f...

The results of a study by researchers at the University of Texas Medical Branch may pave the way for a new medicine delivery system that could reduce the incidence of pre-term labor and premature birth by allowing physicians to treat the 'fetus as the patient'.

Can transgenic mice studies illuminate neurological complications associated with SARS-CoV-2 in humans? The potentially deadly coronavirus disease 2019 (COVID-19) that has swept the world over the last 12 months has not affected animals with corresponding severity. In order to understand the mechanism of severe disease, animal models have been used. This includes a mouse model that expresses human angiotensin-converting enzyme 2 (hACE2) under the cytokeratin 18 promoter (K18-hACE2). A new preprint appearing on the bioRxiv* server indicates that this may not be a faithful model of human letha...

Study may help develop more effective personalized immunotherapy for cancer patients New research from CU Cancer Center member Jing Hong Wang, MD, PhD, and recent University of Colorado Immunology program graduate Rachel Woolaver, PhD, may help researchers develop more effective personalized immunotherapy for cancer patients. Working within Wang's specialty of cancer immunology and head and neck squamous cell carcinomas (HNSCCs), the researchers worked to establish a mouse model that would help them understand why some hosts' immune systems reject tumors easily, while others have a harder tim...