"Multifunctional bismuth oxide (Bi2O3) particles: Evidence for selectiv" by Marcela Laura Chaki Borrás, Georgia Colbran et al.
The current study investigates the therapeutic and optical properties of bismuth oxide (Bi2O3) particles for selective melanoma therapy and prevention. The Bi2O3 particles were prepared using a standard precipitation method. The Bi2O3 particles induced apoptosis in human A375 melanoma cells but not human HaCaT keratinocytes or CCD-1090Sk fibroblast cells. This selective apoptosis appears to be associated with a combination of factors: increased particle internalization (2.29 ± 0.41, 1.16 ± 0.08 and 1.66 ± 0.22-fold of control) and enhanced production of reactive oxygen species (ROS) (3.4 ±...
Source: uow.edu.au