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Was there more to the bloody clue than met the eye? forensic specialist anna cox was trying to unlock what her naked eyes could not see. when she did, her discovery would send the investigation in a completely different direction. here is dennis murphy with written in blood. >> the handwriting was on the wall and forensic specialist anna cox was intent on breaking down the three letters in blood, roc. you would spend hours looking at these letters? >> i did. >> you actually cut the sheet rock out of your place and took it into your lab? >> yes. i have to look at those letters after everything ...

I used to tell her, what are you doing? he did not deserve her. she wouldn't listen. >> the fights got worse and police were called three separate times to intervene. one time roc allegedly broke down the front door. that was the last straw. karen filed a domestic battery complaint and roc moved out. tim says even a year later, he was still harassing karen about a rolltop desk he left behind. >> she was starting to get scared of him toward the end. >> the issue he had was i got a valuable piece of furniture, i want it back. >> right. but karen said that that was a ruse. >> trying to worm his w...

>> the evidence was overwhelming. karen pannell did not write the letters roc in blood. it was a huge turning point in the case and the best news possible for the ex-boyfriend roc herpick. >> they confirmed 100% she could not have done that. she couldn't have done it. she would have been physically incapable of doing that and it certainly wasn't me. i mean, why would you write your own name on the wall? >> police agree, implicating yourself in a murder just made no sense. roc got moore good news after police checked out his alibi, but he was home at the night of the murder. >> we got his cell ...

38-years-old. >> to be a young, divorced woman, with this awful diagnosis, what do you think that did to her? that's a lot to put on your shoulders. >> right. i think that really affected herself esteem. frankly, i think it had an impact on the kind of men she was attracted to. >> karen came to rely on roc to take her to doctor's appointments and injections. when she asked him to move in, her friends and family thought she was asking for trouble. >>ive think that's true. is it my place to say, well, you need to go find somebody that is going to offer you a better future? >> you can't dictate t...

Stained with blood. roc. what was the murdered woman try to tell the cops? >> all these theories, what does that mean? is that a person, a thing? the clues pointed in so many different direction, it was a total mystery. >> reporter: there's a concept in the law known as a dying declaration. with those three letters scrawled in karen's own blood lead to the apprehension of her own killer. >> coming up, investigators dig into that three-letter mystery. who or what was roc? when "dateline" the new concentrated formula... ...gives you 30% more loads and gently cleans. no stretching