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Ultra-long protein fibrils could help with early Alzheimer's diagnosis

Swiss researchers say atomic force microscopy (AFM) could complement biomarker tests and improve the early diagnosis of Alzheimer's. ....

Peter Nirmalraj , Nanoscale Interfaces Laboratory At Empa , Communications Biology , Dementia Research Synapsis Foundation Switzerland , Department Of Neurology , Nanoscale Interfaces Laboratory , Cantonal Hospital , Nanoscale Interfaces ,

Ultra-long protein fibrils are a signature of severe Alzheimer's disease, study shows

During the course of Alzheimer's disease, protein fibrils appear in the spinal fluid of affected individuals. Empa researchers, together with the Department of Neurology at the Cantonal Hospital in St. Gallen, have now visualized the wide spectrum of protein aggregates from oligomers, protofibrils to fibrils in the spinal fluid. ....

Emily Henderson , Peter Nirmalraj , Nanoscale Interfaces Laboratory At Empa , Franco Regli Foundation , Dementia Research Synapsis Foundation Switzerland , Department Of Neurology , Communications Biology , Cantonal Hospital , Nanoscale Interfaces Laboratory , Nanoscale Interfaces , Lzheimer 39s Disease , Atomic Force Microscopy ,