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Chinese herbal medicine remedy for malaria could treat TB and may slow the evolution of drug resistance

A centuries-old herbal medicine, discovered by Chinese scientists and used to effectively treat malaria, has been found to potentially aid in the treatment of tuberculosis and may slow the evolution of drug resistance. ....

Robert Abramovitch , College Of Veterinary Medicine , Centers For Disease , Michigan State University , Nature Chemical , Disease Control ,

Antibody–peptide inhibitor conjugates: A new path for cancer therapy

Tumor cells often hijack normal physiological processes to support their growth, exploiting proteins that are in charge of essential cell functions. It is therefore important to block the activity of these proteins only in cancer cells without affecting their crucial roles in healthy tissues. For this reason, classical approaches using small molecules that induce systemic inhibition across all cells in the body can lead to severe side effects. ....

Bruno Correia , Elisa Oricchio , Aaron Petruzzella , Nature Chemical Biology , Nature Chemical ,

Novel method creates antibody-peptide inhibitor conjugates with enhanced therapeutic efficacy

Tumor cells often hijack normal physiological processes to support their growth, exploiting proteins that are in charge of essential cell functions. ....

Ecole Polytechnique Federale , Bruno Correia , Elisa Oricchio , Polytechnique Federale De Lausanne , Nature Chemical ,