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Innovative therapies for ischemic stroke: Novel bicarbonate-sensing G protein-coupled receptor shows promise

Innovative therapies for ischemic stroke: Novel bicarbonate-sensing G protein-coupled receptor shows promise
medicalxpress.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from medicalxpress.com Daily Mail and Mail on Sunday newspapers.

Japan , Nobutaka-hattori , Airi-jo-watanabe , Takehiko-yokomizo , Takahiro-osada , Psychoactive-drug-screening-program , Juntendo-university , Nature-communications , Juntendo-university-graduate-school-of-medicine , Juntendo-university-graduate-school ,

Novel Bicarbonate Receptor Shows Promise in Stroke Therapy

Novel Bicarbonate Receptor Shows Promise in Stroke Therapy
miragenews.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from miragenews.com Daily Mail and Mail on Sunday newspapers.

Japan , Sayoko-ihara , Kazushige-touhara , Takehiko-yokomizo , Ryota-hashimoto , Toshiaki-okuno , Nobutaka-hattori , Toshiki-inaba , Osamu-nureki , Tomohiro-nishizawa , Takahiro-osada , Airi-jo-watanabe

Innovative therapies for ischemic stroke: Nov

<p style="text-align:justify"><strong>Optimal pH homeostasis for cellular function is maintained by the acid-base balance through multiple buffering systems, such as the bicarbonate system, across the cell. Shifts in this equilibrium can impact health, prompting a closer look at how cells react under pathological conditions. While past studies have offered insights, several aspects remain unexplored. Researchers from Japan have now discovered a new bicarbonate-sensing receptor that regulates ischemic reperfusion injury and offers therapeutic insights into ischemic stroke treatment.</strong></p>

Japan , Takehiko-yokomizo , Takahiro-osada , Ryota-hashimoto , Toshiki-inaba , Kazushige-touhara , Airi-jo-watanabe , Osamu-nureki , Nobutaka-hattori , Toshiaki-okuno , Sayoko-ihara , Tomohiro-nishizawa

Discovery of bicarbonate-sensing receptor offers therapeutic insights into ischemic stroke treatment

Researchers have identified this receptor in brain mural cells that regulates reperfusion injury.

Japan , Airi-jo-watanabe , Takehiko-yokomizo , Takahiro-osada , Nobutaka-hattori , Juntendo-university-research-promotion-center , Psychoactive-drug-screening-program , Nature-communications , Juntendo-university , University-research-promotion , Ischemic-stroke , Rotein

Innovative therapies for ischemic stroke: Nov

Innovative therapies for ischemic stroke: Nov
eurekalert.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from eurekalert.org Daily Mail and Mail on Sunday newspapers.

Japan , Osamu-nureki , Takehiko-yokomizo , Ryota-hashimoto , Takahiro-osada , Tomohiro-nishizawa , Toshiki-inaba , Nobutaka-hattori , Airi-jo-watanabe , Sayoko-ihara , Kazushige-touhara , Toshiaki-okuno

Japanese Team Develops Serum-Based Test for Parkinson's, Other Synucleinopathies

The assay could allow clinicians to diagnose synucleinopathies like Parkinson's disease without requiring a lumbar puncture to collect cerebrospinal fluid.

Nobutaka-hattori , Mark-frasier , Luis-oliveira , Andrew-siderowf , University-of-pennsylvania-perelman-school-medicine , Michaelj-fox-foundation-for-parkinson-research , Parkinson-progression-markers-initiative , Juntendo-university-school-of-medicine , Japan-juntendo-university , Fox-foundation , Juntendo-university , Nature-medicine

A novel blood serum assay to diagnose neurode

Clusters of abnormally folded α-synuclein proteins, called seeds, trigger the formation of larger aggregates, leading to neurodegenerative disorders known as synucleinopathies. Researchers from Japan have developed a novel assay that can detect α-synuclein seeds in the blood. This new assay is highly sensitive, simple, quick, and can differentiate between synucleinopathies based on structural differences of the amplified seeds. This research was supported by the National Research Program for Neurological Disorders and Mental Health of the Japan Agency for Medical Research and Development (AMED).

Bunkyo-ku , Tokyo , Japan , Saitama , Nagasaki , Yamagata , Kyoto , Luxembourg , Dudelange , Luxemburg , Deborah-mcintyre , Daisuke-taniguchi

Study discovers how new blood serum test detect neurodegenerative disorder

Synucleinopathies are neurodegenerative disorders caused by an aberrant accumulation of a-synuclein, a protein present in the brain and neurons. Incorrect

Ayami-okuzumi , Nobutaka-hattori , Taku-hatano , Gen-matsumoto , Juntendo-university-faculty-of-medicine , Nagasaki-university-school-of-medicine , Juntendo-university-school-of-medicine , Nature-medicine , Associate-professor-ayami-okuzumi , Senior-associate-professor-taku-hatano , Juntendo-university-school , Senior-assistant-professor-gen-matsumoto

Novel assay for identifying individuals with synucleinopathies using serum samples

Synucleinopathies are a group of neurodegenerative diseases caused by the abnormal accumulation α-synuclein, a protein normally found in the brain and neurons. Incorrect folding of α-synuclein leads to formation of 'seeds', which attract more α-synuclein proteins to form larger clumps.

Gen-matsumoto , Taku-hatano , Lily-ramsey , Nobutaka-hattori , Ayami-okuzumi , Nagasaki-university-school-of-medicine , Juntendo-university-faculty-of-medicine , Juntendo-university-school-of-medicine , Nature-medicine , Associate-professor-ayami-okuzumi , Senior-associate-professor-taku-hatano , Juntendo-university-school

Study discovers how new blood serum test detect neurodegenerative disorder

Study discovers how new blood serum test detect neurodegenerative disorder
aninews.in - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from aninews.in Daily Mail and Mail on Sunday newspapers.

Nagasaki , Yamagata , Japan , Tokyo , Nobutaka-hattori , Taku-hatano , Gen-matsumoto , Ayami-okuzumi , Nagasaki-university-school-of-medicine , Juntendo-university-faculty-of-medicine , Juntendo-university-school-of-medicine , Nature-medicine