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THE CANDLE: A brief history on mRNA vaccines, Part II - Vimarsana News

THE CANDLE: A brief history on mRNA vaccines, Part II

It would be hard to pick a single year out that made the creation of the Pfizer and Moderna vaccines possible, but the year 2005 would be in the discussion.

Nucleoside modifications suppress the potential of RNA to activate dendritic cells - Vimarsana News

Nucleoside modifications suppress the potential of RNA to activate dendritic cells

A new paper shows that human TLR3, TLR7, and TLR8 receptors are activated with naturally occurring RNA, but this is eliminated once modified nucleosides such as m5C, m6A, m5U s2U, or pseudouridine are incorporated.