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An alternative mouse model of SARS-CoV-2 infection - Vimarsana News

An alternative mouse model of SARS-CoV-2 infection

Recently, a study has shown the possibility of repurposing hACE2 transgenic mice, primarily raised to study SARS-CoV, to support SARS-CoV-2 infection and pathogenesis.

Even mild SARS-CoV-2 respiratory-only infection can cause long-term neurologic damage - Vimarsana News

Even mild SARS-CoV-2 respiratory-only infection can cause long-term neurologic damage

A new bioRxiv* preprint study led by Michelle Monje of Stanford University in California finds that a mild COVID-19 infection can produce long-term neurological damage. Persistent cognitive complications are one of many symptoms of long COVID, and the latest results suggest the severity of COVID-19 induced brain fog is similar to cancer’s “chemobrain.”

Virus-like particles as delivery vehicles for gene-editing - Vimarsana News

Virus-like particles as delivery vehicles for gene-editing

Scientists deliver gene-editing proteins through the use of engineered virus-like particles, which mediated efficient base editing both in vitro and in vivo.

In vivo generation of engineered CAR T cells can reduce fibrosis and restore cardiac function after heart injury - Vimarsana News

In vivo generation of engineered CAR T cells can reduce fibrosis and restore cardiac function after heart injury

A novel immunotherapy strategy using in vivo generation of transient engineered chimeric antigen receptor (CAR) T cells, through the delivery of modified mRNA, can reduce fibrosis and restore cardiac function in a mouse model of heart failure, researchers report.

Study determines minimally effective dose of clinical candidate gene therapy vector to treat hemophilia A - Vimarsana News

Study determines minimally effective dose of clinical candidate gene therapy vector to treat hemophilia A

Researchers determined the minimally effective dose (MED) of a clinical candidate gene therapy vector for treating hemophilia A.