"Synthesis and Transition Metal-Catalysed Reactivity of Vinyl and Allen" by Melissa Jane Bird
Transition metal-catalysed reactions represent a valuable tool for the construction of sp3-rich, stereodefined molecular scaffolds in a single synthetic step. Though these reactions have garnered considerable attention over the last few decades, recent literature indicates that the fractional sp3 character of drug-like molecules has gradually decreased over the last twenty years. This is in part, due to the increased use of transition metal-catalysed cross-coupling reactions such as the Heck and Suzuki–Miyaura reactions, which allow for the preparation of flat, aromatic molecules in a single...
Source: uow.edu.au