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Uncovers the molecular mechanism behind synapse loss in Alzheimer's disease

Credit: KOREA BRAIN RESEARCH INSTITUTE
Korea Brain Research Institute (KBRI, Pann-Ghill Suh (President)) announced that Dr. Kea Joo Lee and Dr. You-Na Jang of the Neural Circuits Research Group have identified the mechanism causing synaptic loss in Alzheimer s disease as the aberrant expression of RAPGEF2, a synaptic protein.
- The results were published on January 2021, in the online Early View of
Neuropathology and Applied Neurobiology.
(Title) RAPGEF2 mediates oligomeric Aβ-induced synaptic loss and cognitive dysfunction in the 3xTg-AD mouse model of Alzheimer s disease
Alzheimer s disease (AD) accounts for about 75% of dementia cases and is the most common type of degenerative brain disease. AD is a devastating because disease progression can cause memory loss, mood disorder, slurred speech, confusion, and impaired movement. ....

South Korea , Kea Joo Lee , Pann Ghill Suh , National Research Foundation Of Korea , Korea Brain Research Institute , Neural Circuits Research Group , You Na Jang , Early View , National Research Foundation , Medicine Health , Alzheimers Disease , தெற்கு கொரியா , கீ ஜூ லீ , தேசிய ஆராய்ச்சி அடித்தளம் ஆஃப் கொரியா , கொரியா மூளை ஆராய்ச்சி நிறுவனம் , நரம்பியல் சுற்றுகள் ஆராய்ச்சி குழு , நீங்கள் நா ஜங் , ஆரம்ப பார்வை , தேசிய ஆராய்ச்சி அடித்தளம் , மருந்து ஆரோக்கியம் , அல்சைமர் நோய் ,