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New research has discovered an important breakthrough that may overcome cancer treatment resistance. The immune system has a naturally occurring brake that tells the body to silence key killer immune cells called CD8+ T-cells as a safeguard to restrain excessive immune responses. Cancer cells are known to exploit this process, called exhaustion, by hijacking the immune system at this off-switch to dampen down the immune attack on cancer, enabling cancer growth. ....

Chris Goodnow , Fabio Luciano , Peter Mac Group Leader Dr , Head Of The Immunogenomics Laboratory At Garvan , Garvan Institute Of Medical Research , Peter Mac , Group Leader , Brian Parish , Professor Fabio Luciano , Professor Chris Goodnow , Garvan Institute , Immunogenomics Laboratory , Willem Van Der Byl ,