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A genetic variant of TMPRSS2 may confer protection against severe COVID-19 Among a large sample of coronavirus disease 2019 (COVID-19) patients, researchers found that a genetic variant – caused by an amino acid substitution from valine to methionine – is associated with a reduced chance of severe disease. Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of COVID-19, can have a diverse range of effects on people. Some people develop no symptoms; some have mild fever, sore throat, among other symptoms; whereas in others, the infection becomes...

Researchers studied SARS-CoV-2 viral loads in over a thousand individuals, including both adults and children. They found the loads to be comparable, suggesting they may play an equal role in COVID-19 transmission.

When researchers analyzed the responses of the COVID-19 Symptom Survey in the United States, they found an increased risk of COVID-19 for household members when children had in-person schooling.

Researchers found a small molecule that inhibits different virus proteins and significantly reduces infection in cells. Combined with the antiviral remdesivir, its potency increases significantly, suggesting it may be a potential antiviral candidate for the treatment of COVID-19.

In a paper published on the bioRxiv preprint server, researchers reported the results on whether IL-13 expression in asthma patients reduces their susceptibility to SARS-CoV-2 infection.