Bold Therapeutics Secures Funding to Prepare BOLD-100 for COVID-19 Clinical Trials
COVID-19 cases continue to escalate worldwide The original announcement by the National Research Council of Canada is available at bit.ly/2JRa4fQ. BOLD-100 is a first-in-class ruthenium-based small molecule drug which selectively inhibits stress-induced upregulation of the chaperone protein GRP78. Currently, the investigational treatment is in a Phase 1b clinical trial in gastrointestinal cancer. In cancer, GRP78 plays a critical role in resistance, survival and proliferation, whereas in viral infections, GRP78 plays a critical role in host recognition, viral entry and viral replication. Prec...