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Deep learning-based splice-AI can help predict the onset of Alzheimer's disease

Deep learning-based splice-AI can help predict the onset of Alzheimer s disease
Korea Brain Research Institute (KBRI, President Suh Pann-ghill) announced that the research team led by Dr. Jae-Yeol Joo discovered new cryptic splice variants and SNVs in PLCg1 gene of AD-specific models for the first time using Splice-AI.
This research outcome was published in
PNAS, a world-renowned academic journal.
Prediction of Alzheimer s Disease-Specific phospholipase c gamma-1 SNV by Deep Learning-Based Approach for High-Throughput Screening
Alternative splicing variant regulates gene expression and influences diverse phenotypes. Especially, genetic variants arising due to RNA splicing are frequently found in individuals having neurodevelopmental disorders. ....

South Korea , Suh Pann Ghill , Jae Yeol Joo , Emily Henderson , Korea Brain Research Institute , Brain Research Institute , President Suh Pann Ghill , Deep Learning Based Approach , Fourth Industrial Revolution , Alzheimer 39s Disease , Deep Learning , Amino Acid , Corona Virus , Gene Expression , High Throughput Screening , Phospholipase C , தெற்கு கொரியா , எமிலி ஹென்டர்சன் , கொரியா மூளை ஆராய்ச்சி நிறுவனம் , மூளை ஆராய்ச்சி நிறுவனம் , ஆழமான கற்றல் அடிப்படையிலானது அணுகுமுறை , நான்காவது தொழில்துறை புரட்சி , ஆழமான கற்றல் , அமினோ அமிலம் , கொரோனா வைரஸ் , கீந் வெளிப்பாடு ,

Predicts the onset of Alzheimer's Disease (AD) using deep learning-based Splice-AI

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IMAGE: High-throughput total RNA-seq profile for PLCγ1 and PLCβ subfamily gene expression in the cortex
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Credit: KBRI
Korea Brain Research Institute (KBRI, President Suh Pann-ghill) announced that the research team led by Dr. Jae-Yeol Joo discovered new cryptic splice variants and SNVs in PLCg1 gene of AD-specific models for the first time using Splice-AI.
This research outcome was published in
PNAS, a world-renowned academic journal.
(Title) Prediction of Alzheimer s Disease-Specific phospholipase c gamma-1 SNV by Deep Learning-Based Approach for High-Throughput Screening
Alternative splicing variant regulates gene expression and influences diverse phenotypes. Especially, genetic variants arising due to RNA splicing are frequently found in individuals having neurodevelopmental disorders. ....

South Korea , Suh Pann Ghill , Jae Yeol Joo , National Research Foundation Of Korea , Korea Brain Research Institute , President Suh Pann Ghill , Deep Learning Based Approach , Fourth Industrial Revolution , National Research Foundation , Cell Biology , Health Care , Algorithms Models , Medicine Health , தெற்கு கொரியா , தேசிய ஆராய்ச்சி அடித்தளம் ஆஃப் கொரியா , கொரியா மூளை ஆராய்ச்சி நிறுவனம் , ஆழமான கற்றல் அடிப்படையிலானது அணுகுமுறை , நான்காவது தொழில்துறை புரட்சி , தேசிய ஆராய்ச்சி அடித்தளம் , செல் உயிரியல் , ஆரோக்கியம் பராமரிப்பு , மருந்து ஆரோக்கியம் ,