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April 22, 2021 SAKURA, Japan, April 22, 2021 /PRNewswire/ Tokiwa Phytochemical Co., Ltd. (hereinafter Tokiwa ), Japan, is excited to announce the publication of a joint research project with the University of Tokyo on a proprietary extract of Kaempferia parviflora (SIRTMAX (R)), commonly known as black turmeric. The study titled Quercetin 3,5,7,3′,4′-pentamethyl ether from Kaempferia parviflora directly and effectively activates human SIRT1 was published in Communications Biology magazine. The study led by Tokiwa and Professor Koji Nagata reveals that quercetin 3,5,7,3′,4′-pentamethyl ether (KPMF-8), an active compound of SIRTMAX (R), directly binds with SIRT1 protein and activates SIRT1 far effectively than resveratrol (well-known SIRT activator). KPMF-8 interacts with SIRT1 directly and stimulates SIRT1 activity by enhancing the binding affinity of SIRT1 with its substrate, Ac-p53 peptide. The binding affinity between SIRT1 and Ac-p53 peptide was enhanced 8.2-f

Koji nagataPrnewswire tokiwa phytochemical co ltdUniversity of tokyoCommunications biologyTokiwa phytochemical co ltdProfessor koji nagataகோஜி நாகதாபல்கலைக்கழகம் ஆஃப் டோக்கியோதகவல்தொடர்புகள் உயிரியல்