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Frontiers | Review: Insights on Current FDA-Approved Monoclonal Antibodies Against Ebola Virus Infection

1 Abstract The devastating Ebola outbreak in West Africa in 2013-2016 accelerated the progress of several medical countermeasures (MCMs) against Ebola virus disease (EVD). Several IPs were used during that outbreak, but no conclusion on efficacy could be drawn. Only the Randomized Controlled Trial (RCT) on ZMapp was promising but inconclusive. More recently, during the second largest Ebola outbreak in North Kivu and Ituri provinces, Democratic Republic of the Congo (DRC), four IPs (Remdesivir, Regeneron, ZMapp and MAb114) have been evaluated in a RCT, the Pamoja Tulinde Maisha (PALM) study. Two products (Regeneron and MAb114) demonstrated efficacy as compared to the control arm, ZMapp. Very few side effects have been reported. Results from this scientifically sound study led the FDA to license both products, representing a milestone in EVD therapeutic field. These products can be produced relatively inexpensively and can be stockpiled. The administration of mAbs on EVD patients appears ....

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Live oral SARS-CoV-2 vaccine provides partial protection in Rhesus Macaques

Live oral SARS-CoV-2 vaccine provides partial protection in Rhesus Macaques
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Addressing vaccine reluctance and policy hesitancy

Addressing vaccine reluctance and policy hesitancy
Updated:
Updated:
February 25, 2021 12:34 IST
Apart from vaccinating the elderly soon, delaying the second dose of the vaccine will open up slots and save lives
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THOOTHUKUDI, TAMIL NADU, 24/02/2021: Corporation Commissioner Sharanya Ari takes administered the COVID -19 vaccine at Thoothukudi Government medical college hospital on Wednesday. PHOTO : RAJESH N
| Photo Credit: RAJESH N
Apart from vaccinating the elderly soon, delaying the second dose of the vaccine will open up slots and save lives
The fact that only one in 10 healthcare workers returned for the second dose of the COVID-19 vaccine as of February 15 indicates that they have probably understood the advantages of delaying it for 12 weeks that the 12-week interval between the two doses affords considerably better protective efficacy than the four-week interval currently followed in India. ....

Tamil Nadu , Ministry Of Health , Health Minister , Improving Covishield , Corona Virus , Covid 19 Vaccines , Health Care Workers , 12 Week Inter Dose Interval , Protective Efficacy , Vaccine Hesitancy , தமிழ் நாடு , அமைச்சகம் ஆஃப் ஆரோக்கியம் , ஆரோக்கியம் அமைச்சர் , கொரோனா வைரஸ் , ஆரோக்கியம் பராமரிப்பு தொழிலாளர்கள் ,

Could intranasal SARS-CoV-2 vaccines be a practical alternative to intramuscular shots?

Could intranasal SARS-CoV-2 vaccines be a practical alternative to intramuscular shots?
The unchecked advance of the coronavirus disease 2019 (COVID-19) has made it a top public health priority to produce a vaccine capable of inducing a safe and powerful protective response against its causative pathogen: severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). An encouraging new preprint, that appeared on the
bioRxiv server shows the immunogenicity, safety, and protective efficacy, of a Newcastle disease virus (NDV)-based intranasal vector vaccine in animal studies.
A host of candidate vaccines being developed against SARS-CoV-2 use viral vector platforms to present the SARS-CoV-2 spike antigen to the host immune system. Many have used the intramuscular route (i.e., ‘jabs’ or ‘shots’), but the intranasal route allows the development of local or mucosal immunity as well as systemic immunity against the virus. This will allow protection against not just s ....

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